Skip to main content

Design And Development Of Pharmacy

By
Drugs cannot be used for administration in their native forms,and in order to obtain the maximum therapeutic effect, it is formulated or design in to dosage forms such as  Tablets,Capsules,Solutions,Suspension,Ointment etc.

At the compounding level the aim of the formulation pharmacists is to design a patient acceptable and reasonably stable dosage form to fulfill the intention of the prescribing physician.The compounding Pharmacists has to Design and Develop such formulation that can satisfy the following aspects :
  1. Dispensing requirements of product improvement to sit medical and consumer preference,such as new dosage form,new package or new pack size.
  2. Call of compounding department for shorts-cuts in processing to improve compounding rate.
  3. Call of physician to develop and supply of product for sale and effective treatment of his patient.
  4. Call to patient to provide safe,economic and convenient to handle and easy to administer dosage form.
The dosage form is compounded on the basis of physico-chemical incompatibilities between drug-drug,drug-additive,,product-container and expected therapeutic efficiency of the product.The Pharmacists,on the basis of knowledge acquired, selects additives to build physical,chemical stability and biological activity in the product.

Pharmaceutical Additives are substances which are of little or no therapeutic value but are added to the formulations in order to ease the production,to maintain stability,to improve patient acceptability,and functioning of dosage form as a drug delivery system.They are also known as Pharmaceutical Aids,-necessities,-adjuncts,-adjuvant,-or excipients.
  • Physiologically Inert.
  • Must be non-toxic, non-irritant,non-sensitizing.
  • Does not impart any undesirable taste,odour or colour to the product.
  • Should be effective in low concentration.
  • Must not interfere with the bio-availability of the drug.
  •  Must be accepted by regulatory authorities.
1)To produce particular dosage form-
  • Diluents or filler for solid dosage forms.
  • Vehicles or solvents for liquid dosage forms.
  • Semi-solid bases for ointments,creams,jellies.
  • Propellants for aerosols and sprays.
2)To attain and maintain physical of formulation-
  • Co-solvents,solubilising agents for solutions.
  • Suspending or emulsifying agents for disperse system.
  • Binders,disintegrating agents for solid dosage forms.
3)To maintain and attain chemical stability of formulations-
  • Antioxidants
  • Buffers
4)Organoleptic additives-
  • Colouring agents.
  • Flavouring agents and perfumes.
  • Sweetening agents.
The Pharmacists,in addition to scientific knowledge,uses his artistic sense for selection of colour,flavour and sweetening agent to impart compatibility and contain minimum required ingredients.The compound Product should maintain its stability for a month.

In short,compound development is a creative work of designing and developing a new product and encompass various activities such as development of new drug or improvement of existing product.

Pharmacists Thought
Keep Your Friend Close,But Your Enemies Closer By Opening A 24 Hours Pharmacies Next To Their Door.
Atlas you are here,so don't forget to like share and subscribe our blog:

Also for interesting Thought,Quotes And Shayrees,click on:

Comments

Post a Comment

Recommended

Compounding And Dispensing In Pharmacy

By
Dispensing in pharmacy is the branch of pharmacy which is concerned with compounding and distribution of medicament's.It involves reading of prescription,checking the prescription,packing,labelling,and dispensing pharmaceutical products.Thus dispensing pharmacy mainly works in two fields,compounding and dispensing. COMPOUNDING : Compounding is extemporaneous preparation of a pharmaceutical products according to formula prescribed in the prescription or in the pharmacopoeia. The pharmacist evaluate the formulation for incompatibility,toxicity and stability in the final container. DISPENSING : Dispensing is defined as the supply of pharmaceutical products to an individual patient ,his representatives or an owner of an animal in response to prescription written by a medical practitioner.The products dispensed to the patients may be compounded in pharmacy in quantity written in prescription.Patients counselling is integral part of dispensing. MANUFACTURING :   Manufacturing is...
18 comments
Read more

Pharmaceutical Aids And Necessities - Acids And Bases

By
This Blog shows discussion of several topics important to the preparation,preservation and storage of pharmaceutical products.The major topics include ACIDS and BASES - frequently employed in the conversion of drugs to chemical forms convenient to their product formulation;BUFFERS - used to maintain the pH of various formulations within Prescribed Limits .
2 comments
Read more

Types Of Prescription

By
There are 3 types of prescription which are as follows : CENTRAL GOVERNMENT HEALTH SCHEME PRESCRIPTION (CGHS)  : These prescription are for those who come under the health scheme of the government. These are not charged but levy charges may be taken. After Dispensing the medicines,prescription are sent to the account section for pricing. The prescription bears common information and a column for pricing. PRIVATE PRESCRIPTION  : Prescriptions are fully charged. These bears the same format as a typical prescription. Except drugs of controlled class,these prescriptions are returned to the patients. HOSPITAL PHARMACY : These include Two types  IN - PATIENT PRESCRIPTION : Prescription for in-patient are written on the physician's order form.The physician order forms are prepared in multiple copies for utilization in the pharmacy,in the nursing station and to attach to the patient medication record.The prescription bears information regarding hospital name,ward nu...
3 comments
Read more

Compounding Of Medication

By
Compounding is the process of extemporaneous preparation of dosage form  on receipt of prescription.Today relatively few prescription involve compounding, but the pharmacists mus still possess the knowledge and skills of compounding that he formerly did so that he can prepare special formulation.The steps of compounding of mediation are as follows :- 1) RECEIVING PRESCRIPTION : Prescription should be received by the pharmacists.Immediately the pharmacists should check patient name, age and whether it is handled by patient in person.While receiving the prescription the pharmacists in no way should facial or verbal expression, express doubts which may shake the faith of the patient in the physician. 2) READING TH PRESCRIPTION : Pharmacists should read the prescription thoroughly in privacy.If necessary, he can consult with another pharmacists or a physician without arousing doubts or fears in the patients mind. Pharmacists should maintain PATIENT MEDICAL RECORD (PMR) ...
1 comment
Read more